Full-Time Postdoc in Fibre and Polymer Technology
Postdoc in Fibre and Polymer Technology
A postdoctoral position is available in the project ”Bioengered Smart materials: A tissue-like multifunctional 3D scaffold” financed by Swedish Research Council.
We have during the last three years developed methods so that we today can design degradable scaffolds with a functional surface. It is now time to implement those results in the research about myeloma. The functional scaffolds should establish an in vitro 3D system for studying growth of primary myeloma in an authentic microenvironment.
Multiple myeloma affect about 500 persons every year, it is a type of cancer that starts in the bone marrow. Today is an animal model used to compare the growth of human marrow and myeloma cells, human bone denuded of cells are implanted into nude mice (that have no immune system). In the nude mouse you have many cytokines and growth factors circulating in the blood that may influence what grows and how the cells grow, but these will not be present in cultures using the scaffolds, so there is a chance to compare what happens when the cells (both normal and myeloma) are exposed to specific manipulations in vitro relative to what happens in the SCID-hu mouse model. This is a fantastic possibility to have two such systems where one can be manipulated factor by factor and one is in an animal without an immune system. This will help in the development of novel therapies and the emergence of myelodysplasia/secondary malignancies.
- The successful applicant must at the time for employment hold a PhD degree or submitted his/her PhD thesis;
- The successful applicant must have experience with polymers and scaffolds in combination with cell culture techniques, research animals, injection techniques, and small animal imaging (for example MRI, PET/CT or optical). She/he must have strong skills experience in subcutaneous animal models and in vitro techniques;
- The candidate should have experience of growing mesenchymal stem cells in 3D models;
- The candidate should be proficient in spoken and written English. Personal skills will be emphasized;
- The candidate should be able to work independently and interactively in a team setting, be motivated and responsible, and also have a strong commitment and enthusiasm for research.